A new study published this week reveals how the prescription diuretic Bumetamide reduces the symptoms of autism.
Interestingly, the drug treats swelling and works by repairing the neurotransmitter-related “GABA switch” (excitatory-to-inhibitory GABA switch) in the brains of autistic children.
There are however side effects and potential concerns because the drug can cause dehydration and electrolyte depletion-both crucial elements in addressing a child with autism.
On the hopeful side, this study shows another link between inflammation, and complex brain and/or nervous system disorders like Autism. It may follow that by lowering inflammation in the body, neurotransmitter function can be restored in autistic children, and may explain why some kids respond to functional medicine testing and treatment for digestive, nutrient and immune related imbalances that cause systemic inflammation.
Clinically, I recommend testing to see if taking nutrients like butyrate (and not taking GABA) is a better option for resolving symptoms in autistic children who are not responding well to treatment.